Comparative Pathogenesis of Three Human and Zoonotic SARS-CoV Strains in Cynomolgus Macaques
Identifieur interne : 002143 ( Main/Exploration ); précédent : 002142; suivant : 002144Comparative Pathogenesis of Three Human and Zoonotic SARS-CoV Strains in Cynomolgus Macaques
Auteurs : Barry Rockx [États-Unis] ; Friederike Feldmann [États-Unis] ; Douglas Brining [États-Unis] ; Don Gardner [États-Unis] ; Rachel Lacasse [États-Unis] ; Lisa Kercher [États-Unis] ; Dan Long [États-Unis] ; Rebecca Rosenke [États-Unis] ; Kimmo Virtaneva [États-Unis] ; Daniel E. Sturdevant [États-Unis] ; Stephen F. Porcella [États-Unis] ; John Mattoon [États-Unis] ; Michael Parnell [États-Unis] ; Ralph S. Baric [États-Unis] ; Heinz Feldmann [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2011.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Syndrome respiratoire aigu sévère.
- biosynthèse : Cytokines.
- physiologie : Virus du SRAS.
- transmission : Animaux, Humains, Immunohistochimie, Macaca fascicularis, Réplication virale, Syndrome respiratoire aigu sévère, Zoonoses.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Cytokines.
- pathology : Severe Acute Respiratory Syndrome.
- physiology : SARS Virus.
- transmission : Severe Acute Respiratory Syndrome.
- Animals, Humans, Immunohistochemistry, Macaca fascicularis, Virus Replication, Zoonoses.
Abstract
The severe acute respiratory syndrome (SARS) epidemic was characterized by increased pathogenicity in the elderly due to an early exacerbated innate host response. SARS-CoV is a zoonotic pathogen that entered the human population through an intermediate host like the palm civet. To prevent future introductions of zoonotic SARS-CoV strains and subsequent transmission into the human population, heterologous disease models are needed to test the efficacy of vaccines and therapeutics against both late human and zoonotic isolates. Here we show that both human and zoonotic SARS-CoV strains can infect cynomolgus macaques and resulted in radiological as well as histopathological changes similar to those seen in mild human cases. Viral replication was higher in animals infected with a late human phase isolate compared to a zoonotic isolate. While there were significant differences in the number of host genes differentially regulated during the host responses between the three SARS-CoV strains, the top pathways and functions were similar and only apparent early during infection with the majority of genes associated with interferon signaling pathways. This study characterizes critical disease models in the evaluation and licensure of therapeutic strategies against SARS-CoV for human use.
Url:
DOI: 10.1371/journal.pone.0018558
PubMed: 21533129
PubMed Central: 3080360
Affiliations:
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Le document en format XML
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sortKey="Rockx, Barry" sort="Rockx, Barry" uniqKey="Rockx B" first="Barry" last="Rockx">Barry Rockx</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Departments of Pathology and Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology and Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Brining, Douglas" sort="Brining, Douglas" uniqKey="Brining D" first="Douglas" last="Brining">Douglas Brining</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Gardner, Don" sort="Gardner, Don" uniqKey="Gardner D" first="Don" last="Gardner">Don Gardner</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Lacasse, Rachel" sort="Lacasse, Rachel" uniqKey="Lacasse R" first="Rachel" last="Lacasse">Rachel Lacasse</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Kercher, Lisa" sort="Kercher, Lisa" uniqKey="Kercher L" first="Lisa" last="Kercher">Lisa Kercher</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Long, Dan" sort="Long, Dan" uniqKey="Long D" first="Dan" last="Long">Dan Long</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Rosenke, Rebecca" sort="Rosenke, Rebecca" uniqKey="Rosenke R" first="Rebecca" last="Rosenke">Rebecca Rosenke</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Virtaneva, Kimmo" sort="Virtaneva, Kimmo" uniqKey="Virtaneva K" first="Kimmo" last="Virtaneva">Kimmo Virtaneva</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Genomics Unit, Research Technologies Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomics Unit, Research Technologies Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Sturdevant, Daniel E" sort="Sturdevant, Daniel E" uniqKey="Sturdevant D" first="Daniel E." last="Sturdevant">Daniel E. Sturdevant</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Genomics Unit, Research Technologies Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomics Unit, Research Technologies Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Porcella, Stephen F" sort="Porcella, Stephen F" uniqKey="Porcella S" first="Stephen F." last="Porcella">Stephen F. Porcella</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Genomics Unit, Research Technologies Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomics Unit, Research Technologies Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Mattoon, John" sort="Mattoon, John" uniqKey="Mattoon J" first="John" last="Mattoon">John Mattoon</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Veterinary Clinical Sciences, Washington State University, Pullman, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary Clinical Sciences, Washington State University, Pullman, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Parnell, Michael" sort="Parnell, Michael" uniqKey="Parnell M" first="Michael" last="Parnell">Michael Parnell</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cytokines (biosynthesis)</term><term>Humans</term><term>Immunohistochemistry</term><term>Macaca fascicularis</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (transmission)</term><term>Virus Replication</term><term>Zoonoses</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cytokines (biosynthèse)</term><term>Humains</term><term>Immunohistochimie</term><term>Macaca fascicularis</term><term>Réplication virale</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (transmission)</term><term>Virus du SRAS (physiologie)</term><term>Zoonoses</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Immunohistochemistry</term><term>Macaca fascicularis</term><term>Virus Replication</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Immunohistochimie</term><term>Macaca fascicularis</term><term>Réplication virale</term><term>Syndrome respiratoire aigu sévère</term><term>Zoonoses</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The severe acute respiratory syndrome (SARS) epidemic was characterized by increased pathogenicity in the elderly due to an early exacerbated innate host response. SARS-CoV is a zoonotic pathogen that entered the human population through an intermediate host like the palm civet. To prevent future introductions of zoonotic SARS-CoV strains and subsequent transmission into the human population, heterologous disease models are needed to test the efficacy of vaccines and therapeutics against both late human and zoonotic isolates. Here we show that both human and zoonotic SARS-CoV strains can infect cynomolgus macaques and resulted in radiological as well as histopathological changes similar to those seen in mild human cases. Viral replication was higher in animals infected with a late human phase isolate compared to a zoonotic isolate. While there were significant differences in the number of host genes differentially regulated during the host responses between the three SARS-CoV strains, the top pathways and functions were similar and only apparent early during infection with the majority of genes associated with interferon signaling pathways. This study characterizes critical disease models in the evaluation and licensure of therapeutic strategies against SARS-CoV for human use.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chan Yeung, M" uniqKey="Chan Yeung M">M Chan-Yeung</name></author><author><name sortKey="Xu, Rh" uniqKey="Xu R">RH Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chinese, Smec" uniqKey="Chinese S">SMEC Chinese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z Shi</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M Yu</name></author><author><name sortKey="Ren, W" uniqKey="Ren W">W Ren</name></author><author><name sortKey="Smith, C" uniqKey="Smith C">C Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, M" uniqKey="Liu M">M 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uniqKey="Yang P">PC Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name></author><author><name sortKey="Donaldson, E" uniqKey="Donaldson E">E Donaldson</name></author><author><name sortKey="Frieman, M" uniqKey="Frieman M">M Frieman</name></author><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T Sheahan</name></author><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Virtaneva, K" uniqKey="Virtaneva K">K Virtaneva</name></author><author><name sortKey="Porcella, Sf" uniqKey="Porcella S">SF Porcella</name></author><author><name sortKey="Graham, Mr" uniqKey="Graham M">MR Graham</name></author><author><name sortKey="Ireland, Rm" uniqKey="Ireland R">RM Ireland</name></author><author><name sortKey="Johnson, Ca" uniqKey="Johnson C">CA Johnson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Montana</li><li>Texas</li><li>Washington (État)</li></region></list><tree><country name="États-Unis"><region name="Montana"><name sortKey="Rockx, Barry" sort="Rockx, Barry" uniqKey="Rockx B" first="Barry" last="Rockx">Barry Rockx</name></region><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><name sortKey="Brining, Douglas" sort="Brining, Douglas" uniqKey="Brining D" first="Douglas" last="Brining">Douglas Brining</name><name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><name sortKey="Gardner, Don" sort="Gardner, Don" uniqKey="Gardner D" first="Don" last="Gardner">Don Gardner</name><name sortKey="Kercher, Lisa" sort="Kercher, Lisa" uniqKey="Kercher L" first="Lisa" last="Kercher">Lisa Kercher</name><name sortKey="Lacasse, Rachel" sort="Lacasse, Rachel" uniqKey="Lacasse R" first="Rachel" last="Lacasse">Rachel Lacasse</name><name sortKey="Long, Dan" sort="Long, Dan" uniqKey="Long D" first="Dan" last="Long">Dan Long</name><name sortKey="Mattoon, John" sort="Mattoon, John" uniqKey="Mattoon J" first="John" last="Mattoon">John Mattoon</name><name sortKey="Parnell, Michael" sort="Parnell, Michael" uniqKey="Parnell M" first="Michael" last="Parnell">Michael Parnell</name><name sortKey="Porcella, Stephen F" sort="Porcella, Stephen F" uniqKey="Porcella S" first="Stephen F." last="Porcella">Stephen F. Porcella</name><name sortKey="Rockx, Barry" sort="Rockx, Barry" uniqKey="Rockx B" first="Barry" last="Rockx">Barry Rockx</name><name sortKey="Rosenke, Rebecca" sort="Rosenke, Rebecca" uniqKey="Rosenke R" first="Rebecca" last="Rosenke">Rebecca Rosenke</name><name sortKey="Sturdevant, Daniel E" sort="Sturdevant, Daniel E" uniqKey="Sturdevant D" first="Daniel E." last="Sturdevant">Daniel E. Sturdevant</name><name sortKey="Virtaneva, Kimmo" sort="Virtaneva, Kimmo" uniqKey="Virtaneva K" first="Kimmo" last="Virtaneva">Kimmo Virtaneva</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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